Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury

Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury

traumatic brain injury (TBI) is a heterogeneous condition, associated with diverse etiology, clinical presentation and severity, and can lead to chronic neurobehavioral sequelae. The rapidly growing field of TBI biomarkers to address many aspects of TBI pathology and improve clinical management. recent years have witnessed a marked increase in the number of publications and interest in the role of extracellular vesicles (EV), which includes exosomes, cell signaling, immune responses, and as a biomarker in a number of pathologies.

Exosomes have defined lipid bilayer well with surface marker that reflects the cell of origin and essence of water containing various biological materials including proteins (eg, cytokines and growth factors) and nucleic acids (eg, microRNAs). The presence of proteins associated with neurodegenerative changes such as amyloid-β, α-synuclein and tau phosphorylated at exosomes suggests a role in the initiation and propagation of nerve disease. However, the mechanism of cell communication in the brain involving exosomes and their role in pathology TBI are poorly understood. Exosomes promising biomarker TBI because they can pass through the blood-brain barrier and can be isolated from peripheral fluids, including serum, saliva, sweat, and urine.

Exosomal content is protected from enzymatic degradation by the exosome membrane and reflects the internal environment of the cell of origin, offer insight into the specific pathological process of tissue. The challenge in clinical use as a biomarker exosomal cargo including difficulty in isolating exosomes pure isolation process variable results, quantification of vesicles, and the lack of specificity markers exosomal.

In addition, there is no consensus on the nomenclature and characteristics of subtypes EV. In this review, we discuss the current technical limitations and challenges of using exosomes and other EVs as blood-based biomarkers, highlighting their potential as diagnostic and prognostic tool in TBI.

 Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury
Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury

MicroRNA-127-5p attenuates severe pneumonia with tumor necrosis factor receptor-associated factor 1

Pneumonia is a persistent and pervasive diseases, the effects of which can be severe. MicroRNA (mir) -127-5p has been used as a new biomarker for the diagnosis of severe pneumonia. This study aims to determine the function of miR-127-5p for severe pneumonia. An in vitro model of severe pneumonia in Ana-1 murine macrophages were established using lipopolysaccharide (LPS). Furthermore, reverse transcription-quantitative PCR and ELISA performed to detect mRNA and protein expression levels of interleukin (IL) -1β, IL-6 and tumor necrosis factor (TNF) -α. Western blotting was also performed to measure the activity of Akt and NF-kB.

The results showed that compared with the control group, LPS treatment increased by a factor 1 (TRAF1) associated TNF receptor expression levels and reduce the expression levels of miR-127-5p. Furthermore, the results revealed that the 3′-translated region of TRAF1 targeted by miR-127-5p. mir-127-5p rose mimic reduced LPS-induced IL-1β, IL-6 and TNF-α expression by targeting TRAF1, potentially mediated by inactivation of AKT and NF-kB signaling pathway.

Stomach-Pylorus Lysate

21-325 0.1 mg
EUR 468.6
Description: Monkey (Rhesus) stomach-pylorus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Rhesus) stomach-pylorus tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach-pylorus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach-pylorus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Fetal Stomach Lysate

XBL-10423 0.1 mg
EUR 500.1
Description: Fetal human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Stomach Membrane Lysate

XBL-10924 0.1 mg
EUR 619.8
Description: Human stomach tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Mouse Stomach OptiTDS: Tissue Dissociation System

4-28202 1 Kit Ask for price

cDNA from Mouse Normal Tissue: Stomach

C1334248 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rat Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Medium

9-25085 5 x 100 ml Ask for price

Human Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Medium

9-46104 5 x 100 ml Ask for price

Human Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells

9-80104 1 x 100 ml Ask for price

Rat Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells

9-80292 1 x 100 ml Ask for price

Stomach Tissue Slide (Normal)

10-801-10um 10 um
EUR 241.8

Stomach Tissue Slide (Normal)

10-801-4um 4 um
EUR 216.6

Stomach Tissue Slide (Benign)

10-803-10um 10 um
EUR 241.8

Stomach Tissue Slide (Benign)

10-803-4um 4 um
EUR 216.6

Stomach Tissue Slide (Adenocarcinoma)

10-809-10um 10 um
EUR 241.8

Stomach Tissue Slide (Adenocarcinoma)

10-809-4um 4 um
EUR 216.6

Stomach Tissue Slide (Carcinoma)

10-814-10um 10 um
EUR 241.8

Stomach Tissue Slide (Carcinoma)

10-814-4um 4 um
EUR 216.6

Stomach Tissue Slide (Abnormal)

10-826-10um 10 um
EUR 241.8

Stomach Tissue Slide (Abnormal)

10-826-4um 4 um
EUR 216.6

Stomach Tissue Slide (Tumor)

10-827-10um 10 um
EUR 241.8

Stomach Tissue Slide (Tumor)

10-827-4um 4 um
EUR 216.6

Human Stomach Tissue Lysate

30R-AS039 150 ug
EUR 262.8
Description: Fresh tissue lysate isolated from human stomach

Stomach Tissue Lysate (Normal)

1717-01 0.1 mg
EUR 260.7
Description: Stomach tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

cDNA from Lupus: stomach

C1236248Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Stomach Tumor lysate

HTL-1340 1 mg
EUR 927.6

Stomach Diabetic Disease Lysate

XBL-10387 0.1 mg
EUR 796.2
Description: Human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Stomach Membrane Tumor Lysate

XBL-10936 0.1 mg
EUR 752.1
Description: Human stomach tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Cardia Membrane Lysate

XBL-10939 0.1 mg
EUR 619.8
Description: Human stomach: Cardia tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: Cardia tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: Cardia tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: Cardia tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Corpus Cytoplasmic Lysate

XBL-10941 0.1 mg
EUR 273.3
Description: Human stomach: corpus tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human stomach: corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: corpus tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: corpus tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Stomach-Corpus Membrane Lysate

XBL-10942 0.1 mg
EUR 619.8
Description: Human stomach: corpus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: corpus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: corpus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Fundus Membrane Lysate

XBL-10945 0.1 mg
EUR 619.8
Description: Human stomach: fundus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: fundus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: fundus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: fundus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Stomach-Pylorus Membrane Lysate

XBL-10948 0.1 mg
EUR 619.8
Description: Human stomach: Pylorus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human stomach: Pylorus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated stomach: Pylorus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated stomach: Pylorus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Genomic DNA from Mouse Normal Tissue: Stomach

D1334248 100 ug
EUR 338.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Mouse Normal Tissue: Stomach

P1334248 1 mg
EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Immortalized Mouse Stomach Epithelial Cells-Conditionally (ImSt)

T0569 1x106 cells / 1.0 ml Ask for price

Total RNA from Mouse Normal Tissue: Stomach

R1334248-50 50 ug
EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mouse Stomach PrimaCell: Normal Stomach Mucosa Epithelial Cells Growth Supplements with Serum (for 500 ml medium)

9-33088 1 Set Ask for price

Stomach Tissue Slide (Malignant Tumor)

10-807-10um 10 um
EUR 241.8

Stomach Tissue Slide (Malignant Tumor)

10-807-4um 4 um
EUR 216.6

Stomach Tissue Slide (mucinous Adenocarcinoma)

10-810-10um 10 um
EUR 241.8

Stomach Tissue Slide (mucinous Adenocarcinoma)

10-810-4um 4 um
EUR 216.6

Stomach Lysate (0 Day Old)

1415-0 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (0 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate (14 Day Old)

1415-14 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (14 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Stomach Lysate (7 Day Old)

1415-7 0.1 mg
EUR 229.2
Description: Stomach tissue lysate (7 Day Old) was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Total RNA from Lupus: Stomach

R1236248Lup-50 50 ug
EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Stomach Tissue Slide (Malignant Tumor)

RF10002-05-10um 10 um
EUR 241.8

Stomach Tissue Slide (Malignant Tumor)

RF10002-05-4um 4 um
EUR 216.6

Rat Stomach Whole tissue lysate

RAL-1475 1 mg
EUR 628.8

mmu-miRNome MicroRNA Profiling Kit [Mouse]

RA670A-1 20 profiles
EUR 2046

MicroRNA Isolation Kit

KS341025 1 kit
EUR 307.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Epithelial Dissociation System 10 (Stomach epithelial), Mouse and Rat

4-20260 ea Ask for price

Human, Mouse, Rat - Stomach Tissue Array (5 slides/pk)

TAS-1013 1 pk
EUR 343.2

Matched Pair Tissue Slides - Stomach Tissue

10-800-MPPT 1 pack
EUR 241.8
Description: The Matched Pair Paraffin Tissue (MPPT) slides are designed for identifying tumor-specific/metastasis genes or proteins. Slices from normal and malignant tissues are mounted on each MPPT slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. This format allows a rapid analysis of protein expression and localization across normal and cancerous tissue.

Multiple Species Tissue Slides - Stomach Tissue

10-800-MSTA 1 pack
EUR 241.8
Description: The Multiple Species Tissue Array (MSTA) slides were designed to study protein expression patterns in different cells and tissues from multiple species. Tissue slices from three different species are mounted on each MSTA slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. This format allows a rapid analysis of protein expression and localization across different species. MSTA slides can also be used to quickly determine the species reactivity of a given antibody.

Human Stomach OptiTDS: Tissue Dissociation System

4-28104 1 Kit Ask for price

Rat Stomach OptiTDS: Tissue Dissociation System

4-28292 1 Kit Ask for price

Human Cancer PrimaCell16: Stomach Tumor Cells

2-96039 1 Kit Ask for price

cDNA from Human Tumor Tissue: Stomach

C1235248 40 reactions
EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Diabetic Tissue: Stomach

C1236248Dia 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Stomach

C1434248 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Stomach

C1734248 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Frozen Tissue Section - Human Tumor: Stomach

T1235248 5 slides
EUR 405.6
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total RNA from Diabetic Disease: Stomach

R1236248Dia-50 50 ug
EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mouse pre-microRNA Expression Construct mir-100

MMIR-100-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-101a

MMIR-101a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-101b

MMIR-101b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-101c

MMIR-101c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-105

MMIR-105-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-106a

MMIR-106a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-106b

MMIR-106b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-107

MMIR-107-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-10a

MMIR-10a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-10b

MMIR-10b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-122

MMIR-122-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-125a

MMIR-125a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-126

MMIR-126-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-127

MMIR-127-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-130a

MMIR-130a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-130b

MMIR-130b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-132

MMIR-132-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-133b

MMIR-133b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-134

MMIR-134-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-135b

MMIR-135b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-136

MMIR-136-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-139

MMIR-139-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-140

MMIR-140-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-141

MMIR-141-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-142

MMIR-142-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-143

MMIR-143-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-145

MMIR-145-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-146a

MMIR-146a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-146b

MMIR-146b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-148a

MMIR-148a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-149

MMIR-149-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-150

MMIR-150-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-151

MMIR-151-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-152

MMIR-152-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-153

MMIR-153-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-154

MMIR-154-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-155

MMIR-155-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-181c

MMIR-181c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-181d

MMIR-181d-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-182

MMIR-182-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-183

MMIR-183-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-184

MMIR-184-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-185

MMIR-185-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-186

MMIR-186-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-187

MMIR-187-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-188

MMIR-188-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-18b

MMIR-18b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-190

MMIR-190-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-190b

MMIR-190b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-191

MMIR-191-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-192

MMIR-192-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-193

MMIR-193-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-193b

MMIR-193b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-195

MMIR-195-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-196b

MMIR-196b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-1b

MMIR-1b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-200a

MMIR-200a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-200b

MMIR-200b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-200c

MMIR-200c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-201

MMIR-201-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-202

MMIR-202-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-203

MMIR-203-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-204

MMIR-204-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-205

MMIR-205-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-206

MMIR-206-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-207

MMIR-207-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-208a

MMIR-208a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-208b

MMIR-208b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-20b

MMIR-20b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-21

MMIR-21-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-210

MMIR-210-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-211

MMIR-211-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-212

MMIR-212-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-214

MMIR-214-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-215

MMIR-215-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-216a

MMIR-216a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-216b

MMIR-216b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-217

MMIR-217-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-22

MMIR-22-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-221

MMIR-221-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-222

MMIR-222-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-223

MMIR-223-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-224

MMIR-224-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-23b

MMIR-23b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-26b

MMIR-26b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-27b

MMIR-27b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-28

MMIR-28-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-2861

MMIR-2861-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-28b

MMIR-28b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-28c

MMIR-28c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-291b

MMIR-291b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-296

MMIR-296-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-297b

MMIR-297b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-297c

MMIR-297c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-298

MMIR-298-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-299

MMIR-299-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-29a

MMIR-29a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-29c

MMIR-29c-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-300

MMIR-300-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-301a

MMIR-301a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-301b

MMIR-301b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-302b

MMIR-302b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-30a

MMIR-30a-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-30b

MMIR-30b-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-30d

MMIR-30d-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-30e

MMIR-30e-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-31

MMIR-31-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-32

MMIR-32-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-320

MMIR-320-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-322

MMIR-322-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-323

MMIR-323-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-324

MMIR-324-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-325

MMIR-325-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-326

MMIR-326-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-327

MMIR-327-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-328

MMIR-328-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-329

MMIR-329-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-33

MMIR-33-PA-1 Bacterial Streak
EUR 820.8

Mouse pre-microRNA Expression Construct mir-330

MMIR-330-PA-1 Bacterial Streak
EUR 820.8

Collectively, the results suggest that miR-127-5p may attenuate severe pneumonia by reducing the production of inflammatory cytokines LPS-induced, and disable the AKT and NF-kB signaling pathway by targeting TRAF1.

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