Inhibiting roles of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448/PON1/TLR3/NF-κB axis

What is the main question of this study? This study aims to explore the OIP5-AS1 lncRNA function in rheumatoid arthritis inflammation and development and molecular mechanisms. What are the main findings and importance? LncRNA relieve rheumatoid arthritis OIP5-AS1 through the network Cerna developments involving miR-448 / PON1 axis and through inactivation of TLR3 / NF-kB signaling pathway. This research may offer new ideas for molecular-based control for rheumatoid arthritis Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder with dysregulation of long non-coding RNA (lncRNAs) may be involved.

This study aims to inquire into OIP5-AS1 lncRNA role in the development of RA. A mouse model with RA induced. Excess of OIP5-AS1 are introduced in a mouse model, and then change leg swelling, RA severity and inflammatory factors IL-1β, IL-10, IL-6 and TNF-α measured. Fibroblast like synoviocytes (FLS) from RA patients were collected for in vitro experiments. Gain- and loss of function OIP5-AS1, miR-448 and paraoxonase 1 (PON1) is conducted to explore their role in RA-FLS growth, apoptosis, and inflammation. A specific TLR3 agonist or antagonist PIC-specific NF-kB QNZ was administered in RA-FLS. As a result, overexpression OIP5-AS1 reduce symptoms and severity and levels of inflammatory factors in rats RA.

OIP5-AS1 can bind to miR-448 to enhance the expression of PON1. Further excess miR-448-AS1 OIP5 reverse effect, while overexpression of PON1 inhibits the growth of RA-FLS and inflammation. In addition, activation of TLR3 promoted the development of RA. To conclude, this study demonstrated that lncRNA OIP5-AS1 can reduce the progression of RA through the miR-448 / PON1 axis and through inactivation of TLR3 / NF-kB signaling pathway. This article is protected by copyright. All rights reserved.

 Inhibiting roles of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448/PON1/TLR3/NF-κB axis
Inhibiting roles of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448/PON1/TLR3/NF-κB axis

Perk-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

Oxidative / nitrosative stress is a major trigger of cardiac dysfunction, which involves a folded protein response and mitochondrial dysfunction. Activation of the nitric oxide-cyclic guanosine monophosphate kinase G-protein signaling by sildenafil increases the heart mal-remodeling during heart failure-induced excess pressure. Transcriptome analysis conducted in heart failure with or without sildenafil treatment. Protein kinase R-like endoplasmic reticulum (ER) kinase (perk) downstream signaling pathways, EIF2 and NRF2, significantly altered.

Although EIF2 signal is suppressed, NRF2 signaling is upregulated, inhibits the maturation of miR-24-3p through EGFR mediated phosphorylation Ago2. To study the effects of sildenafil on this path, we produce specific heart perk KO mice. In these mice, sildenafil could not inhibit maturations, nuclear translocation NRF2 pressed, and advanced mitochondrial dysfunction. Overall, these results suggest that the perk-mediated suppression miRNAs by sildenafil is essential for maintaining homeostasis of mitochondria through oxidative stress response NRF2-mediated.


Lef-1 role in the development of ectodermal organs have been characterized using Lef-1 knockout murine models. We produce lef-1 conditional over-expression (Coel) mouse to determine the role of Lef-1 expression in epithelial structure at the final stage of development after the endogenous expression of the switch to the mesenchyme. Let-1 over expression (OE) in the oral epithelium creating new niche dental epithelial stem cells that significantly enhance the growth of the incisors.

Rat Skeletal Muscles Frozen Sections

RF-102 10 slides
EUR 228

Rat WS Skeletal Muscles Total RNA

RR-102-WS 0.05mg
EUR 160

Rat Skeletal Muscles Paraffin Sections

RP-102 10 slides
EUR 228

Dog Skeletal Muscles RNA

DR-102 0.05mg
EUR 195

Rat WS Skeletal Muscles Total Protein

RT-102-WS 1mg
EUR 153

Cat Skeletal Muscles cDNA

FD-102 30 Reactions
EUR 280

Dog Skeletal Muscles cDNA

DD-102 30 Reactions
EUR 280

Pig Skeletal Muscles cDNA

PD-102 30 reactions
EUR 243

Rat WS Skeletal Muscles Frozen Sections

RF-102-WS 10 slides
EUR 228

Sheep Skeletal Muscles cDNA

SD-102 30 reactions
EUR 243

Equine Skeletal Muscles cDNA

ED-102 30 reactions
EUR 319

Bovine Skeletal Muscles cDNA

BD-102 30 reactions
EUR 243

Rabbit Skeletal Muscles cDNA

TD-102 30 reactions
EUR 243

Rat WS Skeletal Muscles Paraffin Sections

RP-102-WS 10 slides
EUR 228

Rat Skeletal Muscles cDNA-Random Primer

RD-102-RH 30 reactions
EUR 243

Chicken Skeletal Muscles cDNA

CD-102 30 reactions
EUR 243

Hamster Skeletal Muscles cDNA

AD-102 30 reactions
EUR 243

MiniPig Skeletal Muscles cDNA

ND-102 30 reactions
EUR 358

Rat WS Skeletal Muscles cDNA-Oligo-dT

RD-102-WS 30 reactions
EUR 243

Chicken Skeletal Muscles Sections

CP-102 10 slides
EUR 240

Rat Skeletal Muscles Developmental Western Blot

RW-102-D 1 Blot
EUR 789

Cat Skeletal Muscles Total RNA

FR-102 0.05mg
EUR 195

Rat Skeletal Muscles Developmental Northern Blot

RN-102-D 1 Blot
EUR 789

Mouse CD1 Skeletal Muscles cDNA

MD-102 30 reactions
EUR 243

Mouse BLC Skeletal Muscles cDNA

MD-102-BLC 30 reactions
EUR 280

Mouse C57 Skeletal Muscles cDNA

MD-102-C57 30 reactions
EUR 280

Cat Skeletal Muscles Genomic DNA

FG-102 0.1mg
EUR 210

Dog Skeletal Muscles Genomic DNA

DG-102 0.1mg
EUR 210

Guinea Pig Skeletal Muscles cDNA

GD-102 30 reactions
EUR 243

Sheep Skeletal Muscles Total RNA

SR-102 0.05mg
EUR 160

Human Skeletal Muscles Total RNA

HR-102 0.025mg
EUR 172

Pig Skeletal Muscles Genomic DNA

PG-102 0.1mg
EUR 177

Equine Skeletal Muscles Total RNA

ER-102 0.05mg
EUR 195

Bovine Skeletal Muscles Total RNA

BR-102 0.05mg
EUR 160

Rabbit Skeletal Muscles Total RNA

TR-102 0.05mg
EUR 160

Dog Skeletal Muscles Total Protein

DT-102 1mg
EUR 176

Cat Skeletal Muscles Total Protein

FT-102 1mg
EUR 176

Hamster Skeletal Muscles Total RNA

AR-102 0.05mg
EUR 160

Chicken Skeletal Muscles Total RNA

CR-102 0.05mg
EUR 160

Human Skeletal Muscles Genomic DNA

HG-102 0.05mg
EUR 210

MiniPig Skeletal Muscles Total RNA

NR-102 0.05mg
EUR 231

Pig Skeletal Muscles Total Protein

PT-102 1mg
EUR 153

Mouse Skeletal Muscles Genomic DNA

MG-102 0.1mg
EUR 177

Sheep Skeletal Muscles Genomic DNA

SG-102 0.1mg
EUR 177

Bovine Skeletal Muscles Genomic DNA

BG-102 0.1mg
EUR 177

Equine Skeletal Muscles Genomic DNA

GE-102 0.1mg
EUR 210

Rabbit Skeletal Muscles Genomic DNA

TG-102 0.1mg
EUR 177

Monkey Skeletal Muscles cDNA, Rhesus

UD-102 30 reactions
EUR 316

Hamster Skeletal Muscles Genomic DNA

GA-102 0.1mg
EUR 177

Cat Skeletal Muscles Frozen Sections

FF-102 10 slides
EUR 261

Chicken Skeletal Muscles Genomic DNA

GC-102 0.1mg
EUR 177

Dog Skeletal Muscles Frozen Sections

DF-102 10 slides
EUR 261

Sheep Skeletal Muscles Total Protein

ST-102 1mg
EUR 153

Human Skeletal Muscles Total Protein

HT-102 1mg
EUR 176

Pig Skeletal Muscles Frozen Sections

PF-102 10 slides
EUR 261

Equine Skeletal Muscles Total protein

ET-102 1mg
EUR 176

Bovine Skeletal Muscles Total Protein

BT-102 1mg
EUR 153

Rabbit Skeletal Muscles Total Protein

TT-102 1mg
EUR 153

Dog Skeletal Muscles paraffin Sections

DP-102 10 slides
EUR 240

Chicken Skeletal Muscles Total Protein

CT-102 1mg
EUR 153

Cat Skeletal Muscles Paraffin Sections

FP-102 10 slides
EUR 240

Hamster Skeletal Muscles Total Protein

AT-102 1mg
EUR 153

Human Skeletal Muscles Frozen Sections

HF-102 10slides
EUR 240

MiniPig Skeletal Muscles Total Protein

NT-102 1mg
EUR 176

Sheep Skeletal Muscles Frozen Sections

SF-102 10 slides
EUR 261

Equine Skeletal Muscles Frozen Sections

EF-102 10 slides
EUR 261

Bovine Skeletal Muscles Frozen Sections

BF-102 10 slides
EUR 261

Mouse Skeletal Muscles Developmental NB

MN-102-D 1 Blot
EUR 789

Rabbit Skeletal Muscles Frozen Sections

TF-102 10 slides
EUR 240

Mouse CD1 Skeletal Muscles Total RNA

MR-102 0.05mg
EUR 160

Mouse C57 Skeletal Muscles Total RNA

MR-102-C57 0.05mg
EUR 180

Hamster Skeletal Muscles Frozen Sections

AF-102 10 slides
EUR 240

Chicken Skeletal Muscles Frozen Sections

CF-102 10 slides
EUR 261

Sheep Skeletal Muscles Paraffin Sections

SP-102 10 slides
EUR 240

Human Skeletal Muscles Paraffin Sections

HP-102 10 slides
EUR 228

MiniPig Skeletal Muscles Frozen Sections

NF-102 10 slides
EUR 307

Guinea Pig Skeletal Muscles Total RNA

GR-102 0.05mg
EUR 160

Mini Pig Skeletal Muscles Genomic DNA

GN-102 0.1mg
EUR 210

Bovine Skeletal Muscles Paraffin Sections

BP-102 10 slides
EUR 240

Mouse Balbc Skeletal Muscles Total RNA

MR-102-BLC 0.05mg
EUR 180

Mouse C57 Skeletal Muscles Genomic DNA

MG-102-C57 0.025mg
EUR 210

Hamster Skeletal Muscles Paraffin Sections

AP-102 10 slides
EUR 228

MiniPig Skeletal Muscles Paraffin Sections

NP-102 10 slides
EUR 307

Guinea Pig Skeletal Muscles Genomic DNA

GG-102 0.1mg
EUR 177

Human Skeletal Muscles cDNA-Oligo-dT

HD-102 30 reactions
EUR 280

Mouse CD1 Skeletal Muscles Total Protein

MT-102 1mg
EUR 153

Mouse BLC Skeletal Muscles Total Protein

MT-102-BLC 1mg
EUR 180

Mouse C57 Skeletal Muscles Total Protein

MT-102-C57 1mg
EUR 180

Monkey Skeletal Muscles Total RNA, Rhesus

UR-102 0.05mg
EUR 195

Guinea Pig Skeletal Muscles Total Protein

GT-102 1mg
EUR 153

Mouse CD1 Skeletal Muscles Frozen Sections

MF-102 10 slides
EUR 228

Mouse BLC Skeletal Muscles Frozen Sections

MF-102-BLC 10 slides
EUR 253

Mouse C57 Skeletal Muscles Frozen Sections

MF-102-C57 10 slides
EUR 253

Monkey Rhesus Skeletal Muscles Genomic DNA

UG-102 0.1mg
EUR 210

Human Skeletal Muscles cDNA-Random Primer

HD-102-HR 30 reactions
EUR 280

Guinea Pig Skeletal Muscles Frozen Sections

GF-102 10 slides
EUR 240

Mouse CD1 Skeletal Muscles Paraffin Sections

MP-102 10 slides
EUR 228

Mouse BLC Skeletal Muscles Paraffin Sections

MP-102-BLC 10 slides
EUR 253

Mouse C57 Skeletal Muscles Paraffin Sections

MP-102-C57 10 slides
EUR 253

Monkey Skeletal Muscles Total RNA, Cynomolgus

KR-102 0.05mg
EUR 195

Monkey Skeletal Muscles Total Protein, Rhesus

UT-102 1mg
EUR 176

Guinea Pig Skeletal Muscles Paraffin Sections

GP-102 10 slides
EUR 228

Monkey Cynomolgus Skeletal Muscles Genomic DNA

KG-102 0.1mg
EUR 210

Monkey Skeletal Muscles Total Protein, Cynomolgus

KT-102 1mg
EUR 176

Mouse Skeletal Muscles Developmental Western Blot

MW-102-D 1 Blot
EUR 789

Mouse C57 Skeletal Muscles cDNA-Random Primer

MD-102-C57-RH 30 reactions
EUR 280

Mouse CD1 Skeletal Muscles cDNA-Random Primer

MD-102-HR 30 reactions
EUR 243

Rat Skeletal Muscles Developmental Total Protein Panel, 6 stages

RT-102-006D 6x0.1mg
EUR 998

Monkey Skeletal Muscles cDNA-Random Primer, Rhesus

UD-102-RH 30 reactions
EUR 316

Troponin C, slow skeletal and cardiac muscles

AP79091 1mg
EUR 2640

Troponin C, slow skeletal and cardiac muscles

AP89148 1mg
EUR 2640

Troponin C, slow skeletal and cardiac muscles

AP89174 1mg
EUR 2640

Troponin C, slow skeletal and cardiac muscles

AP88631 1mg
EUR 2640

Troponin C, slow skeletal and cardiac muscles

AP88889 1mg
EUR 2640

Rat Skeletal Muscles Developmental Total Protein Panel, any 10 stages

RT-102-010D 10x0.1mg
EUR 1289

Monkey Skeletal Muscles cDNA-Random Primer, Cynomolgus

KD-102-RH 30 reactions
EUR 316

Rat Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

EK12296 96Т
EUR 799

Rat Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

AE63354RA-48Tests 48 Tests
EUR 325
Description: Rat (Rattus norvegicus)

Rat Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

AE63354RA-96Tests 96 Tests
EUR 610
Description: Rat (Rattus norvegicus)

ELISA kit for Rat Troponin C, slow skeletal and cardiac muscles (TNNC1)

KTE101020-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Rat Troponin C, slow skeletal and cardiac muscles (TNNC1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Troponin C, slow skeletal and cardiac muscles (TNNC1)

KTE101020-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Rat Troponin C, slow skeletal and cardiac muscles (TNNC1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Troponin C, slow skeletal and cardiac muscles (TNNC1)

KTE101020-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Rat Troponin C, slow skeletal and cardiac muscles (TNNC1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx238835-100ug 100 ug
EUR 610.8

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

20-abx001574
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx018671-100ul 100 ul
EUR 410.4

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx001574-100l 100 µl
EUR 400

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx001574-20l 20 µl
EUR 175

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx001574-50l 50 µl
EUR 275

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx111401-100l 100 µl
EUR 612.5

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx018671-1mg 1 mg
EUR 262.5

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx238835-100l 100 µl Ask for price

Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) Antibody

abx238835-50l 50 µl
EUR 350

Human Troponin C, slow skeletal and cardiac muscles ELISA Kit

EK3670 96 tests
EUR 739

Porcine Troponin C, slow skeletal and cardiac muscles, TNNC1 ELI

ELI-39993p 96 Tests
EUR 1113.6

Human Troponin C, slow skeletal and cardiac muscles, TNNC1 ELISA

ELI-40072h 96 Tests
EUR 988.8

Mouse Troponin C, slow skeletal and cardiac muscles, Tnnc1 ELISA

ELI-36461m 96 Tests
EUR 1038

Bovine Troponin C, slow skeletal and cardiac muscles, TNNC1 ELIS

ELI-17222b 96 Tests
EUR 1113.6

Human Troponin C, Slow Skeletal and Cardiac Muscles (TNNC1) Protein

abx680515-10g 10 µg
EUR 225

Human Troponin C, Slow Skeletal and Cardiac Muscles (TNNC1) Protein

abx680515-50g 50 µg
EUR 325

Pig Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555672-96tests 96 tests
EUR 1093.2

Cow Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555769-96tests 96 tests
EUR 1093.2

Pig Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555672-1096tests 10 × 96 tests Ask for price

Pig Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555672-596tests 5 × 96 tests Ask for price

Cow Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555769-1096tests 10 × 96 tests Ask for price

Cow Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555769-596tests 5 × 96 tests Ask for price

Pig TNNC1 / Troponin C, slow skeletal and cardiac muscles ELISA Kit

E15120p 96T
EUR 900

Goat Troponin C, slow skeletal and cardiac muscles (TNNC6) ELISA Kit

EK12301 96Т
EUR 799

Goat Troponin C, slow skeletal and cardiac muscles (TNNC6) ELISA Kit

AE63359GO-48Tests 48 Tests
EUR 345
Description: Goat (Capra hircus; Caprine)

Goat Troponin C, slow skeletal and cardiac muscles (TNNC6) ELISA Kit

AE63359GO-96Tests 96 Tests
EUR 650
Description: Goat (Capra hircus; Caprine)

Mouse Troponin C, slow skeletal and cardiac muscles(TNNC1) Elisa kit

EK731764 96 Wells
EUR 0.82

Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

EK6167 96Т
EUR 799

Human TNNC1/ Troponin C, slow skeletal and cardiac muscles ELISA Kit

E2558Hu 1 Kit
EUR 515
Description: TNNC

Horse Troponin C, slow skeletal and cardiac muscles (TNNC4) ELISA Kit

EK12299 96Т
EUR 799

Human Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555435-96tests 96 tests
EUR 943.2

Mouse Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx555608-96tests 96 tests
EUR 886.8

Human Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

abx352187-96tests 96 tests
EUR 943.2

Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

AE13934MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

AE13934MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Horse Troponin C, slow skeletal and cardiac muscles (TNNC4) ELISA Kit

AE63357HO-48Tests 48 Tests
EUR 360
Description: Horse (Equus caballus; Equine)

Horse Troponin C, slow skeletal and cardiac muscles (TNNC4) ELISA Kit

AE63357HO-96Tests 96 Tests
EUR 680
Description: Horse (Equus caballus; Equine)

Human Troponin C, Slow Skeletal And Cardiac Muscles (TNNC1) ELISA Kit

20-abx153332
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

KTE70102-48T 48T
EUR 339
Description: This Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit employs a two-site sandwich ELISA to quantitate TNNC1.

Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit

KTE70102-96T 96T
EUR 589
Description: This Mouse Troponin C, slow skeletal and cardiac muscles (TNNC1) ELISA Kit employs a two-site sandwich ELISA to quantitate TNNC1.

These data indicate that Lef-1 expression is switched off in the dental epithelium at an early stage to maintain the stem cell niche and set incisors growth. Bioinformatics analysis showed that the expression of miR-26b increases coincided with a decrease in Lef-1 expression in epithelial teeth.